Low-Dose Nocturnal Dexmedetomidine Prevents ICU Delirium A Randomized, Placebo-controlled Trial

Delirium in critically ill adults independently predicts longer hospital stay and higher costs and mortality and may alter cognitive recovery (1). No pharmacological preventive intervention administered to critically ill adults without delirium has been shown to reduce delirium incidence. The etiology and pathophysiology of ICU delirium remains poorly understood. Most studies describing it use imperfect screening tools that may be confounded by sedation depth. However, sedative choice may influence delirium occurrence.